Is Zantac safe to take in pregnancy. I am nearly 33 weeks pregnant (1st pregnancy) and have been suffering from painful heartburn in the past 12 hours. I went to the chemist and they gave me zantac and told me it was safe, but when i opened the box i saw it said not to take during pregnancy. I rang my local gp and the receptionist looked up something and said that i shouldn`t really take it. The pain wasn`t easing so i rang the maternity ward at my local hospital and they told me that it was fine to take. I`m confused and uncomfortable? What should I do?